Synthetic lethality clusters in metabolic networks
2018/01/26 | academic
Synthetic lethality, in which the combined knockout of two nonessential genes or reactions is lethal, has direct applications in recognising targets for therapeutic treatment of complex diseases and for fighting against undesired resistance. We propose a change of paradigm based on the fact that SL interactions in metabolism are not independent of each other but form complex backup systems, called SL clusters.