Synthetic lethality, in which the combined knockout of two nonessential genes or reactions is lethal, has direct applications in recognising targets for therapeutic treatment of complex diseases and for fighting against undesired resistance. We propose a change of paradigm based on the fact that SL interactions in metabolism are not independent of each other but form complex backup systems, called SL clusters.

The World Trade Atlas 1870-2013 is a collection of annual World Trade Maps where distance integrates the different dimensions affecting international trade beyond geography. The Atlas informs us about the long-run evolution of the international trade system and shows that, in terms of trade, the world is not flat, it is hyperbolic.

MACFANG Workshop, Barcelona | November 6 - 8, 2017

We welcome applications for a three-year PhD position within our program of Complex Networks at UB.

We show that multiplex systems are not random combinations of single network layers. Instead, they are organized in specific ways dictated by hidden geometric correlations between the layers.